Table 4.

Comparisons of area under the curves among the radiomic models and Lung-RADS in the primary and validation cohorts.

Pairwise comparison	Primary cohort		Validation cohort
	Z	P	Z	P
Lung-RADS vs. Radiomic signature of low-dose CT	4.012	0.0001*	2.643	0.0082*
Lung-RADS vs. Radiomic nomogram of low-dose CT	4.123	<0.0001*	2.679	0.0074*
Lung-RADS vs. Radiomic signature of standard-dose CT	3.329	0.0009*	2.732	0.0063*
Lung-RADS vs. Radiomic nomogram of standard-dose CT	3.713	0.0002*	2.798	0.0051*
Radiomic signature of low-dose CT vs. Radiomic nomogram of low-dose CT	0.354	0.7236	<0.001	0.999
Radiomic signature of low-dose CT vs. Radiomic signature of standard-dose CT	1.058	0.2903	0.707	0.4794
Radiomic signature of low-dose CT vs. Radiomic nomogram of standard-dose CT	0.385	0.7003	0.928	0.3534
Radiomic nomogram of low-dose CT vs. Radiomic signature of standard-dose CT	1.037	0.2998	0.599	0.5492
Radiomic nomogram of low-dose CT vs. Radiomic nomogram of standard-dose CT	0.663	0.5075	0.841	0.4003
Radiomic signature of standard-dose CT vs. Radiomic nomogram of standard-dose CT	1.019	0.3084	0.402	0.6877

^*Differences are significant at P < 0.05 corrected with false discovery rate. Lung-RADS, Lung CT Screening Reporting and Data System.