Table 3.
Statistical analysis of the local MA for all possible pairs of nucleotides.
| Pair of nucleotides | Deviation from mean MA | Overlapping HS | Predicted MA (sign) | Experimental MA | P-value(Wilcoxon) | Adjusted p-value | ||
|---|---|---|---|---|---|---|---|---|
| One-sided | Mutual | Sequential | ||||||
| TA | 0.02037 | TA | negative | -0.02097 | 8.55E-34 | 2.28E-33 | ||
| GC | 0.01366 | WGCW | negative | -0.01426 | 1.23E-22 | 2.47E-22 | ||
| A_C | 0.01051 | WARC | negative | -0.01111 | 1.64E-52 | 7.48E-52 | ||
| G_A | 0.00504 | GTA | negative | -0.00565 | 3.83E-38 | 1.36E-37 | ||
| G_T | 0.00470 | GYTW | negative | -0.00531 | 7.63E-34 | 2.22E-33 | ||
| A_A | 0.00408 | 0.00348 | 6.73E-35 | 2.15E-34 | ||||
| AG | 0.00397 | 0.00337 | 2.73E-24 | 5.83E-24 | ||||
| CC | 0.00386 | WRCC | positive | 0.00325 | 1.47E-79 | 1.56E-78 | ||
| CA | 0.00291 | WRCA | positive | 0.00231 | 1.00E-56 | 8.02E-56 | ||
| C_C | 0.00280 | WRCRC | positive | 0.00219 | 9.98E-55 | 6.38E-54 | ||
| GG | 0.00273 | GGYW | positive | 0.00213 | 9.02E-104 | 2.89E-102 | ||
| AA | 0.00258 | WAA | negative | -0.00318 | 1.29E-01 | 1.48E-01 | ||
| G_G | 0.00206 | GYGYW | positive | 0.00145 | 3.40E-53 | 1.81E-52 | ||
| T_T | 0.00179 | 0.00119 | 8.70E-12 | 1.64E-11 | ||||
| GA | 0.00179 | 0.00118 | 1.28E-30 | 3.16E-30 | ||||
| GT | 0.00170 | GTW | negative | -0.00230 | 7.53E-08 | 1.34E-07 | ||
| G_C | 0.00160 | 0.00100 | 2.04E-84 | 3.27E-83 | ||||
| A_T | 0.00146 | 0.00085 | 1.82E-02 | 2.42E-02 | ||||
| TC | 0.00144 | 0.00084 | 3.27E-39 | 1.31E-38 | ||||
| T_G | 0.00132 | -0.00192 | 1.30E-04 | 2.08E-04 | ||||
| TG | 0.00127 | TGYW | positive | 0.00066 | 4.45E-30 | 1.02E-29 | ||
| T_A | 0.00126 | 0.00066 | 3.97E-02 | 4.89E-02 | ||||
| AT | 0.00105 | -0.00165 | 7.22E-02 | 8.56E-02 | ||||
| C_T | 0.00077 | 0.00016 | 2.45E-02 | 3.13E-02 | ||||
| T_C | 0.00076 | TAC | negative | -0.00136 | 7.07E-05 | 1.19E-04 | ||
| C_A | 0.00072 | -0.00132 | 7.40E-03 | 1.13E-02 | ||||
| A_G | 0.00050 | -0.00011 | 8.99E-03 | 1.25E-02 | ||||
| CT | 0.00044 | -0.00016 | 9.16E-01 | 9.16E-01 | ||||
| C_G | 0.00030 | -0.00031 | 4.04E-01 | 4.31E-01 | ||||
| CG | 0.00028 | -0.00032 | 7.86E-03 | 1.14E-02 | ||||
| TT | 0.00021 | TTW | negative | -0.00081 | 5.01E-01 | 5.17E-01 | ||
| AC | 0.00019 | WAC | negative | -0.00079 | 2.44E-01 | 2.70E-01 | ||
Data is sorted based on the deviation from the overall mean MA. Pairs with predicted negative MA are highlighted in blue, positive predictions are highlighted in red. P-values represent significance of the shift between original data MAs and those from the Independent simulations. Non-significant p-values are highlighted in purple, less significant p-values are highlighted in light purple.