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. 2020 Nov 20;124(4):805–816. doi: 10.1038/s41416-020-01166-z

Fig. 5. HOX gene expression is associated with aggressive ACC.

Fig. 5

a Correlation of HOXB9 expression with MKI67, a proliferation gene signature, and CCNE1 in ACC patient samples from the TCGA and Cochin cohorts. b Correlation of HOXC10 expression with MKI67, a proliferation gene signature, and CCNE1 in ACC patient samples from the TCGA and Cochin cohorts. c HOX gene expression in ACC samples from patients with aggressive C1A or indolent C1B-type disease from the TCGA cohort. Statistical analysis a Wilcoxon test, ***P < 0.001. d HOX gene expression in normal human adrenals (NAd), adrenocortical adenoma (ACA) samples, and adrenocortical carcinoma (ACC) samples from the Cochin cohort. Statistical analysis is one-way ANOVA Turkey’s pairwise test, ***P < 0.001, **P < 0.01, *P < 0.05. e Kaplan–Meier survival curves for ACC patients from the TCGA and Cochin cohorts that had either high or low HOXC10 or HOXD13 expression.