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. 2021 Feb 2;10:615375. doi: 10.3389/fonc.2020.615375

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Copyright © 2021 Scully, Ettela, LeRoith and Gallagher

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential mechanisms linking obesity and type 2 diabetes and cancer. The relationship between type 2 diabetes, obesity, and cancer is potentially mediated by multiple mechanisms, including metabolic conditions such as hyperinsulinemia and dyslipidemia as well as the alteration of adipose tissue which is characterized by inflammation and a tumor growth-promoting secretory profile. Stars indicate factors discussed in this review. Adapted from: Gallagher, E.J., and LeRoith, D (2015). Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality. Physiol. Rev. 95, 727–748.