TABLE 1.
Treatment with Peg-G-CSF alone, Ghrelin alone, or the combination of both impacts survival, body weight, WBCs, RBCs, platelets, spleen weight and splenocytes after RI. Survival, body weight, numbers of WBCs, RBCs, and platelets, spleen weight, and splenocytes were reduced after RI and remained low 30 days later. Comparisons are made from data pooled from three separate experiments.
Increases in survival above RI + Veh (%) | Body weight | WBCs | RBCs | Platelets | Spleen weight | Splenocytes | |
---|---|---|---|---|---|---|---|
Peg-G-CSF | 32 | ↓ | ↓ | ↑ | ↓ | ↓ | ↑ |
Ghrelin | 0 | ↓ | ↓ | ↓ | ↑ | ↑ | ↑ |
Peg-G-CSF + ghrelin | 45 | ↑ | ↓ | ↓ | ↑ | ↓ | ↓ |
RI, radiation injury; Veh, vehicles; ↑, increase; ↓, decrease.