TABLE 2.

Residue-based free energy decomposition for Rac1-Tiam1 complex (kcal/mol).

Mutant	VDW	Electrostatic	Polar solvation	Nonpolar	Total
Y32	−4.33	−7.22	8.50	−0.67	−3.73
N39	−3.58	−10.28	11.09	−0.51	−3.28
W56	−2.87	−2.53	1.77	−0.40	−4.04
Y64	−5.78	−2.09	4.02	−0.73	−4.59