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. 2021 Feb 15;11:3001. doi: 10.1038/s41598-020-79275-1

Figure 11.

Figure 11

PTI-00703 Cat’s claw is the most potent disaggregator of tau tangles in comparison to 12 other cat’s claw extracts tested. (A) PTI-00703 Cat’s claw compared to other cat’s claw extracts for % disaggregation of pre-formed tau tangles induced by heparin following 3 days of treatment. Comparisons were made on a wt/wt basis between PTI-00703 Cat’s claw and cat’s claw extracts from Remedy’s Nutrition, elp essential, Pure Mountain BOTANICALS, Best Naturals, PROGRESSIVE LABORATORIES, Peruvian Naturals, PHARMLINE, GRUPO CENTROFLORA, STARWEST BOTANICALS, GoNutra, SWANSON, and RAINTREE FORMULAS. At the 1:0.1 wt/wt dose of tau protein: PTI-00703 Cat’s claw significantly disaggregated tau protein tangles by 34.3%. Cat’s claw extract from GRUPO CENTROFLORA was the closest to the robust activity demonstrated by PTI-00703 Cat’s claw with only 20.2% disaggregation shown at the 1:0.1 wt/wt dose. *p < 0.05, **p < 0.01, ***p < 0.001, by Student’s t-test. Bars represent mean ± SEM. (B) Comparisons of PTI-00703 Cat’s claw to 5 other cat’s claw extracts (including cat’s claw extracts obtained from HERBAL PLUS, NATURE’S HERBS, Nature’s Way, NOW, and SOLARAY). PTI-00703 Cat’s claw caused a robust dose-dependent disaggregation of pre-formed tau tangles, and much better than the other 5 cat’s claw extracts tested. At the 1:0.1 wt/wt dose of Tau-441: PTI-00703 Cat’s claw there was a 50.6% significantly disaggregation of tau protein tangles. *p < 0.05, **p < 0.01, ***p < 0.001, by Student’s t-test. Bars represent mean ± SEM.