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. 2021 Feb 2;11:605967. doi: 10.3389/fphar.2020.605967

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Copyright © 2021 Sun, Cai, Jian, Cui, Huang, Liu, Lu, Wang, Zeng and Zhong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BMP9 treatment attenuates hepatic steatosis in HFD mouse livers. (A) The appearance of the liver and liver weight difference among the three groups. (B) Oil red o staining, HE, sirius red staining of the liver and F4/80 IHC staining in the different groups (original magnification, ×200 or ×100). (C) Histological scoring of steatosis, hepatocyte ballooning and lobular inflammation. (D) The mRNA expression of F4/80 in mouse livers. (E) BMP9 modulated TG but not CHOL levels in the liver. (F) BMP9 downregulated SREBP1 protein expression in the liver. The data are presented as the means ± SEM. Control, n = 6; HFD and HFD+BMP9, n = 8 respectively. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.