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. 2021 Feb 2;11:605967. doi: 10.3389/fphar.2020.605967

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Copyright © 2021 Sun, Cai, Jian, Cui, Huang, Liu, Lu, Wang, Zeng and Zhong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BMP9 reprogrammes transcriptional profiles of HFD-fed mouse livers. (A) Hierarchical cluster analysis of all DEGs in the three groups, n = 3 in each group. p < 0.05, |Log2FC|>1. (B) DEGs with opposite trends in HFD vs Control and HFD+BMP9 vs. HFD, and sixteen DEGs associated with lipid metabolism and inflammation are listed. p < 0.05, |Log2FC|>1. (C) KEGG (Kyoto Encyclopedia of Genes and Genomes) annotation for the upregulated genes between the HFD and Control groups. (D) KEGG annotation for the downregulated DEGs between the HFD+BMP9 and HFD groups. (E) Validation of some DEGs by qRT-PCR in mouse livers. The data are expressed as the means ± SEM. *p < 0.05, **p < 0.01.