Table 2.

Clinical Characteristics of Eight ACC Patients

Case No.	Gender	Age of Onset(Year)	First Symptoms	Stage	Transfer Site	Treatment	Recur	Prognosis
1	Female	7.5	Rash, precocious puberty	II	None	Surgery - chemotherapy	No	CR
2	Female	1.6	Rash, precocious puberty	IV	Lung	Biopsy - Chemotherapy - Surgery - Chemotherapy	No	SD
3	Female	6.5	Rash, precocious puberty	IV	Lung	Surgery-chemotherapy-relapse-surgery, radiation therapy-chemotherapy	Yes	CR
4	Male	6	Abdominal pain	IV	Lung	Biopsy - Chemotherapy - Surgery - Chemotherapy	No	CR
5	Female	4.9	Headache, precocious puberty	IV	Lung, liver	Chemotherapy - Surgery - Chemotherapy	No	Death
6	Female	3.5	Precocious puberty	IV	Lung, liver, lymph node	Chemotherapy - Surgery - Chemotherapy	No	Death
7	Female	12	Abdominal pain	II	None	Surgery - chemotherapy	No	CR
8	Male	6	Headache	IV	Lung, liver	Surgery - chemotherapy	No	SD

Notes: All lesions had completely disappeared for more than four weeks. The primary tumor reduced by ≥ 64%, the metastatic tumor reduced by ≥ 30%, there were no new lesions. The primary tumor increased by ≥40% compared to its size at the initial diagnosis, the metastasis tumor increased by ≥20%, new lesions appeared. Tumor volume was between PD and PR.

Abbreviations: ACC, adrenocortical carcinoma; CR, complete remission; PR, partial remission; PD, disease progression; SD, stable disease.