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. 2021 Feb 11;13:1333–1342. doi: 10.2147/CMAR.S274631

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© 2021 Tian et al.

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ELOVL6 overexpression restores the regulatory effects of apatinib on the expression of ferroptosis-associated proteins via ACSL4. (A–D) The expression of ACSL4, GPx4 and FTH1 was determined using Western blot analysis. ***P<0.001 vs control; ^##P<0.01, ^###P<0.001 vs Oe-NC. (E) The protein–protein interaction network for ELOVL6. (F) Immunoprecipitation was performed with indicated antibodies in HCT116 cells. The immunocomplexes were subjected to Western blot assay.

Abbreviations: ELOVL6, elongation of very long-chain fatty acids family member 6; ACSL4, long-chain acyl-CoA synthetases 4; GPx4, glutathione peroxidase 4; FTH1, ferritin heavy chain.