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. 2021 Feb 11;16:951–976. doi: 10.2147/IJN.S285950

Table 2.

In vitro Release Kinetics and Mechanism from THP Loaded PLGA Nanoparticles

Kinetics of Drug Release Mechanism of Drug Release
Kinetic Models Zero Order First Order Higuchi Model Korsmeyer-Peppas Model
Kinetic Equations Inline graphic Inline graphic Inline graphic Inline graphic
Kinetic Parameters r2 K0 r2 K1 r2 KH r2 Kk n
THP NP 200 nm 0.29 14.23 0.72 0.32 0.87 32.72 0.98 42.27 0.31
THP NP 400 nm 0.34 11.12 0.63 0.19 0.89 25.51 0.99 32.60 0.32

Notes: Qt, Amount of drug dissolved in time t; Q0, initial amount of drug in the solution; K0, zero order release constant; K1, first order release constant; KH, Higuchi dissolution constant; Kk, Korsmeyer′s constant describing the structural and geometrical characteristics of the drug dosage form; n, release exponent, describing the drug release mechanism.