Table 4.
The Changes in the Physicochemical Parameters of THP Loaded PLGA Nanoparticles, mTHPC Encapsulated Liposomes, and LCNPs. The Formulations Were Incubated with PBS (pH 7.4; without Ca2+/Mg2+) at 37 °C for 24 h in a Shaking Incubator. Hydrodynamic Diameter is Expressed as Particle Size Distribution by Intensity. The Results are Expressed as Mean ± SD (n=3)
| Formulation | Time [h] | Diameter [nm] ± SD | PDI ± SD | ζ Potential [mV] ± SD |
|---|---|---|---|---|
| THP NP 200 nm | 0 | 204.70 ± 3.40 | 0.10 ± 0.03 | 7.60 ± 0.34 |
| 1 | 212.40± 3.43 | 0.12 ± 0.02 | 6.18 ± 0.19 | |
| 4 | 220.20 ± 7.40 | 0.13 ± 0.03 | 5.27 ± 0.19 | |
| 24 | 202.70± 3.50 | 0.08 ± 0.02 | 6.28 ± 0.24 | |
| mTHPC-LP | 0 | 108.80 ± 2.10 | 0.19 ± 0.06 | −12.9 ± 0.50 |
| 1 | 105.40 ± 9.51 | 0.21 ± 0.07 | −12.6 ± 1.00 | |
| 4 | 115.00 ± 9.30 | 0.23 ± 0.01 | −15.5 ± 3.40 | |
| 24 | 122.70 ± 8.91 | 0.22 ± 0.01 | −14.0 ± 2.70 | |
| LCNP | 0 | 208.60 ± 2.21 | 0.11 ± 0.01 | 5.90 ± 0.90 |
| 1 | 212.60 ± 4.80 | 0.15 ± 0.04 | 4.24 ± 0.37 | |
| 4 | 220.50 ± 7.17 | 0.17 ± 0.02 | 4.63 ± 0.59 | |
| 24 | 205.30 ± 3.70 | 0.13 ± 0.04 | 4.39 ± 0.23 |