Table 5.

The Changes in the Physicochemical Parameters of THP Loaded PLGA Nanoparticles, mTHPC Encapsulated Liposomes, and Lipid-Coated Nanoparticles. All the Formulations Were Incubated with FCS (60%) at 37 ^°C for 24 h in a Shaking Incubator. Hydrodynamic Diameter is Expressed as Particle Size Distribution by Intensity. The Results are Expressed as Mean ± SD (n=3)

Formulation	Time [h]	Diameter [nm] ± SD	PDI ± SD	ζ Potential [mV] ± SD
THP NP 200 nm	0	204.70 ± 3.40	0.10 ± 0.03	7.60 ± 1.40
	1	195.50 ± 4.30	0.21 ± 0.02	−10.40 ± 1.20
	4	191.82 ± 4.70	0.22 ± 0.04	−15.40± 1.24
	24	179.35 ± 3.80	0.22 ± 0.01	−15.90 ± 1.30
mTHPC-LP	0	108.81 ± 2.10	0.19 ± 0.06	−14.60 ± 1.40
	1	113.23 ± 2.60	0.25 ± 0.01	−13.20 ± 0.51
	4	105.50 ± 4.50	0.27 ± 0.03	−15.00 ± 0.80
	24	101.77 ± 3.40	0.32 ± 0.03	−15.70 ± 0.90
LCNP	0	208.61 ± 2.20	0.11 ± 0.01	5.90 ± 0.96
	1	191.60 ± 9.80	0.22 ± 0.02	−14.60 ± 1.10
	4	180.50 ± 3.10	0.19 ± 0.02	−15.70 ± 1.00
	24	176.52 ± 1.90	0.21 ± 0.01	−15.30 ± 0.70