Table 6.
The Changes in Hematological Parameters in the Blood Serum of Albino Mice After Intravenous Administration of Free mTHPC (DMSO), mTHPC Loaded Liposomes, LCNP, THP PLGA Nanoparticles (200 Nm), Free THP (DMSO), and Normal Saline into the Tail Vein. After 7 Days of Treatment, Blood Was Withdrawn from the Mice and a Complete Blood Count Was Performed. The Values are Expressed as Mean ± S.D (n = 3)
| Biomarker | Free mTHPC | mTHPC-LP | LCNP | THP NP 200 nm | Free THP (DMSO) | Blank |
|---|---|---|---|---|---|---|
| TEC (1012/L) | 5.9 ± 1.6 | 7.0 ± 1.6 | 6.4 ± 1.7 | 6.2 ± 1.2 | 5.4 ± 1.8 | 6.7 ± 1.9 |
| Hb (g/dL) | 10.2 ± 1.8 | 10.5 ± 2.1 | 10.7 ± 1.6 | 10.7 ± 2.2 | 9.8 ± 1.9 | 10.9 ± 1.8 |
| MCV (fL) | 52.3 ± 5.4 | 54.7 ± 4.8 | 59.6 ± 5.4 | 55.5 ± 6.0 | 51.2 ± 5.5 | 58.3 ± 4.2 |
| HCT (%) | 31.6 ± 4.6 | 33.5 ± 5.3 | 32.1 ± 5.1 | 31.5 ± 3.9 | 30.8 ± 6.0 | 32.4 ± 5.6 |
| MCH (pg) | 16.5 ± 2.3 | 17.4 ± 2.6 | 16.8 ± 3.5 | 17.6 ± 2.7 | 18.4 ± 3.4 | 16.3 ± 4.1 |
| MCHC (g/dL) | 34.7 ±2.8 | 33.8 ± 3.1 | 33.1 ± 1.7 | 34.6 ± 2.6 | 30.1 ± 2.9 | 33.6 ± 3.6 |
| TLC (109/L) | 8.7 ± 2.4 | 9.2 ±3.7 | 9.7 ± 3.9 | 8.9 ± 2.5 | 8.2 ± 2.7 | 9.4 ± 3.5 |
| Platelets (109/L) | 705 ± 19 | 714 ± 27 | 738 ± 21 | 726 ± 28 | 693 ± 22 | 758 ± 25 |
| MPV (fL) | 8.0 ± 1.6 | 7.7 ± 2.0 | 7.6 ± 1.8 | 7.9 ± 2.1 | 8.4 ± 2.1 | 7.5 ± 1.9 |