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. 2021 Feb 11;16:1037–1050. doi: 10.2147/IJN.S292528

Figure 4.

Figure 4

Mechanism of MIL-101(Fe)@sor-induced ferroptotic cell death. (A and B) MTT viability assays of HepG2 cells with different treatments. (C) MTT viability assays of HepG2 cells with different treatments and ferroptosis inhibitors. (D and E) MDA and GSH levels in HepG2 cells after different treatments. (F) WB analysis of GPX4 expression in HepG2 cells after different treatments. 1–5: control, MIL-101(Fe), sorafenib, MIL-101(Fe)@sor, and MIL-101(Fe)@sor + iRGD groups, respectively. *p < 0.05, **p < 0.01, ***p < 0.001.