Table 6.
The targeting relationship between 19 overlapping small molecule drugs and their regulated DEmiRNAs, respectively, expressed in DPSC and BMSC osteodifferentiation process. These 19 overlapping small molecular drugs can not only regulate the DEmiRNAs dysregulated in DPSC osteodifferentiation but also regulate the DEmiRNAs dysregulated in BMSC osteodifferentiation.
| Small molecule | Regulated DEmiRNAs involved in DPSC osteodifferentiation | Regulated DEmiRNAs involved in BMSC osteodifferentiation |
|---|---|---|
| 5-fluorouracil | hsa-miR-1246 | hsa-miR-140-3p |
| hsa-miR-146b-5p | hsa-miR-146b-5p | |
| hsa-miR-184 | hsa-miR-342-3p | |
| hsa-miR-210 | hsa-miR-3658 | |
| hsa-miR-4791 | hsa-miR-378i | |
| hsa-miR-671-5p | hsa-miR-423-5p | |
| hsa-miR-574-3p | ||
| hsa-miR-671-5p | ||
| Anthocyanin | hsa-miR-335-5p | hsa-miR-450a-5p |
| Arsenic trioxide | hsa-miR-133b | hsa-miR-146b-5p |
| hsa-miR-146b-5p | hsa-miR-34c-5p | |
| hsa-miR-184 | ||
| hsa-miR-210 | ||
| hsa-miR-34c-5p | ||
| Ascorbate | hsa-miR-1246 | hsa-miR-1972 |
| hsa-miR-134 | ||
| hsa-miR-1973 | ||
| Atorvastatin | hsa-miR-146b-5p | hsa-miR-146b-5p |
| hsa-miR-487a | hsa-miR-224-5p | |
| hsa-miR-548d-5p | ||
| Bromocriptine | hsa-miR-671-5p | hsa-miR-671-5p |
| Curcumin | hsa-miR-210 | hsa-miR-34c-5p |
| hsa-miR-335-5p | hsa-miR-450a-5p | |
| hsa-miR-34c-5p | ||
| Docosahexaenoic acid | hsa-miR-1283 | hsa-miR-141-3p |
| hsa-miR-143-3p | hsa-miR-143-3p | |
| hsa-miR-181a-5p | hsa-miR-191-5p | |
| hsa-miR-193b-3p | ||
| Ginsenoside Rh2 | hsa-miR-210 | hsa-miR-188-5p |
| hsa-miR-3195 | hsa-miR-483-3p | |
| hsa-miR-3656 | hsa-miR-630 | |
| hsa-miR-370 | ||
| hsa-miR-4284 | ||
| Glucose | hsa-miR-133a | hsa-miR-129-5p |
| hsa-miR-133b | hsa-miR-199b-5p | |
| hsa-miR-329 | hsa-miR-342-5p | |
| hsa-miR-34c-5p | hsa-miR-34c-5p | |
| hsa-miR-615-3p | hsa-miR-369-3p | |
| hsa-miR-508-3p | ||
| hsa-miR-520b | ||
| hsa-miR-525-5p | ||
| hsa-miR-548d-5p | ||
| Hesperidin | hsa-miR-133b | hsa-miR-188-5p |
| hsa-miR-450b-3p | ||
| Hydroxycamptothecin (HCPT) | hsa-miR-1246 | hsa-miR-10a-5p |
| hsa-miR-1973 | hsa-miR-135a-3p | |
| hsa-miR-335-3p | hsa-miR-181a-2-3p | |
| hsa-miR-370 | hsa-miR-1972 | |
| hsa-miR-543 | hsa-miR-224-3p | |
| Microcystin-LR (MC-LR) | hsa-miR-671-5p | hsa-miR-671-5p |
| Mistletoe lectin-I | hsa-miR-331-3p | hsa-miR-369-3p |
| hsa-miR-615-3p | hsa-miR-491-3p | |
| Narangin | hsa-miR-671-5p | hsa-miR-188-5p |
| hsa-miR-671-5p | ||
| Proanthocyanin | hsa-miR-133a | hsa-miR-671-5p |
| hsa-miR-133b | ||
| hsa-miR-671-5p | ||
| Progesterone | hsa-miR-146b-5p | hsa-miR-146b-5p |
| hsa-miR-370 | hsa-miR-525-5p | |
| Vitamin D3 | hsa-miR-133b | hsa-miR-339-5p |
| hsa-miR-331-3p | ||
| hsa-miR-543 | ||
| Vorinostat (SAHA) | hsa-miR-134 | hsa-miR-542-3p |
| hsa-miR-409-3p | hsa-miR-574-3p |