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. 2021 Jan 5;96(1):e81–e92. doi: 10.1212/WNL.0000000000011081

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Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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(A) Strongest associations between voxel-based morphometry (VBM) and amnestic AD were observed in lateral temporal, inferior parietal, precuneus, and posterior cingulate cortices. (B) Strongest associations between VBM and behavioral/dysexecutive AD were observed in the lateral temporal, inferior parietal, dorsolateral, and medial prefrontal cortices. (C, D) t Maps displaying no statistically significant differences between patients with behavioral/dysexecutive AD and amnestic AD. t Statistical parametric maps were corrected for multiple comparisons using a random field theory cluster threshold of p < 0.001. Age, sex, and Mini-Mental State Examination were employed as covariates in each model. CU = cognitively unimpaired.