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. 2021 Jan 5;96(1):e81–e92. doi: 10.1212/WNL.0000000000011081

Figure 5. Accuracy of Imaging Biomarkers for Discriminating Behavioral/Dysexecutive (b/d) Alzheimer Disease (AD) From Amnestic AD.

Figure 5

Top row: Area under the receiver operating characteristic (ROC) curve in every brain voxel for amyloid-PET (left), tau-PET (middle), and voxel-based morphometry (VBM) (right). Amyloid-PET showed poor discriminatory accuracy between behavioral/dysexecutive AD and amnestic AD. Area under the receiver operating characteristic curve (AUC) values for tau-PET varied substantially, with highest AUC values being observed in the medial prefrontal cortex, anterior cingulate cortex, and frontal insula, while lower values were observed in posterior cortical regions. Voxel-based morphometry demonstrated low discriminatory accuracy between behavioral/dysexecutive and amnestic AD groups. Bottom row: Percentage of frontal cortex differentially affected in behavioral/dysexecutive AD vs amnestic AD. No differences were observed in frontal cortical amyloid between AD groups (p = 0.46). Significant differences in frontal cortical tau-PET were observed between behavioral/dysexecutive and amnestic AD groups (p = 0.006). No significant differences were observed in frontal cortical voxel-based morphometry between AD groups (p = 0.81).