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. 2021 Feb 2;96(5):e758–e771. doi: 10.1212/WNL.0000000000011315

Figure 3. Association Between the Number of Abnormal Nodes In Surgically Spared Network With Year 1 Surgical Outcome and Relapse.

Figure 3

(A–D) Four patients are shown with their year 1 surgical outcome and relapse information. (A) and (B) Lower abnormality load in patients with International League Against Epilepsy (ILAE) 1 and ILAE 2 outcomes, respectively, with no relapse. (C) Patient with many abnormal nodes remaining yet having an ILAE 2 outcome at year 1 but relapsing subsequently. (D) Large number of abnormal nodes remaining in a patient who was never seizure-free in 5 years. (E) Significantly more abnormal nodes remained in ILAE 3+ patients compared to ILAE 1 and ILAE 2 patients. Statistical estimates: ILAE 1 (n = 34) median 6 (95% confidence interval [CI] 5–7.5); ILAE 2 (n = 8) median 3 (95% CI 2–5.5); ILAE 3+ median 8 (95% CI 5–10); p(ILAE 1 vs ILAE 3+) = 0.005; d(ILAE 1 vs ILAE 3+) = 1.11 (95% CI 0.42–2.2); p(ILAE 2 vs ILAE 3+) = 0.01; d(ILAE 2 vs ILAE 3+) = 0.61 (95% CI −0.92 to 2.04). (F) Alluvial flow diagram showing proportion of relapsed patients with ILAE 1 or ILAE 2 at year 1. (G) In ILAE 1 to 2 patients, those who relapsed had significantly more abnormal nodes in the surgically spared network. Statistical estimates: no relapse (n = 14) median 4.5 (95% CI 4–6); relapse (n = 13) median 8 (95% CI 5–15); p = 0.04; d = 0.77 (95% CI −0.01 to 1.31).