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. 2021 Feb 2;11:593633. doi: 10.3389/fphar.2020.593633

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Copyright © 2021 Yue, Yu, Wang, Liu, Bai and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anthocyanin reduces blood glucose and improves cardiac function in diabetic mice. (A) Blood glucose from 0 to 12 weeks. (B) Left ventricle ejection fraction (LVEF) and (C) Left ventricular fractional shortening (LVFS) are shown. (D) M-mode echocardiograms of left ventricle. (E) Hematoxylin and eosin (HE) and Masson’s trichrome staining. (F) Relative quantification of HE staining. (G) Relative collagen deposition. Scale bar, 50 μm. ***p < 0.001 vs. Control, ##p < 0.01 vs. diabetes mellitus (DM); ###p < 0.001 vs. DM; n = 5.