Table 1.

Summary of HPV ccfDNA results for metastatic cervical patients on HPV-TIL study

Patient	Age	Tumor HPV type	Prior RT	Prior chemo	Therapy	Response	Duration TTP (months)	ccfDNA HPV Detection in blinded test
								No. of samples	No. of positive tests	HPV type	Baseline copies CmL)	No. of negative tests	Duration of negative tests (months)	ccfDNA recurrence
1	30	18	Yes	Yes	HPV-TIL	PD	1	5	5	18	4,347	0	NA	NA
2	53	18	Yes	Yes	HPV-TIL	PR	3	14	10	18	2,002	4	1	Yes
3	36	16	Yes	Yes	HPV-TIL	CR	22+	25	17	16	86	8	12+	No
4	55	16	Yes	Yes	HPV-TIL	PD	2	8	8	16	3,305	0	NA	NA
5	44	18	Yes	Yes	HPV-TIL	PD	2	8	8	18	453	0	NA	NA
6	36	18	Yes	Yes	HPV-TIL	CR	15+	23	13	18	1,193	10	10+	No
7	59	18	Yes	Yes	HPV-TIL	PD	1	6	6	18	3,113	0	NA	NA
8	31	18	No	Yes	HPV-TIL	PD	2	4	4	18	50	0	NA	NA
9	37	18	Yes	Yes	HPV-TIL	PD	1	6	6	18	1,522	0	NA	NA

Abbreviations: ccfDNA, circulating cell-free DNA; CR, complete response; HPV, human papillomavirus; PD, progressive disease; PR, partial response; RT, radiotherapy; TIL, tumor-infiltrating T cells; TTP, time to progression.