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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Neurochem Res. 2020 Jan 11;45(6):1287–1297. doi: 10.1007/s11064-019-02949-4

Fig. 1. Topology model for sodium calcium exchangers of the SLCA8 family.

Fig. 1

The current model for NCX topology proposes five transmembrane helices in both the first and second hydrophobic cluster. The two conserved α-repeats (α1 and α2) contain ion-coordinating amino acid residues that are involved in ion transport activities. The cytosolic f-loop encompasses the two calcium binding domains CBD1 and CBD2, and the exchanger inhibitory peptide (XIP) site, which is present in NCX1 and NCX3 and has been implicated in sodium-dependent inactivation.