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. 2021 Jan 29;21(4):305. doi: 10.3892/etm.2021.9736

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Copyright: © Zhong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Enrichment map of GSEA for KRT15-related genes in BRCA. GSEA results showed datasets (A) ‘REACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION’, (B) PID_FOXO_PATHWAY, (C) ‘PID_DELTA_NP63_PATHWAY’, (D) BIOCARTA_VDR_PATHWAY, (E) BIOCARTA_ARF_PATHWAY, (F) BIOCARTA_CASPASE_PATHWAY and (G) PID_IL27_PATHWAY were significantly enriched in the KRT15 high group, indicating a potential role of KRT15 in BRCA. Datasets (H) ‘BIOCARTA_ACE2_PATHWAY’ and (I) BIOCARTA_GHRELIN_PATHWAY were significantly enriched in the KRT15 low group. NES, normalized enrichment score; FDR, false discovery rate; P adj, adjusted P-value; BRCA, breast invasive carcinoma; KRT15, keratin 15; FOXO, forkhead box O; VDR, vitamin D receptor; ARF, alternative reading frame; ACE2, angiotensin converting enzyme 2.