Table III.
Association between clinicopathological characteristics and overall survival determined by univariate and multivariate Cox regression analysis.
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
| Characteristics | N | HR (95% CI) | P-value | HR (95% CI) | P-value |
| T stage, T1/T2 vs. T3/T4 | 1,061 | 0.598 (0.412-0.868) | 0.007 | 0.413 (0.212-0.806) | 0.01 |
| N stage, N1/N2/N3 vs. N0 | 1,045 | 2.145 (1.497-3.073) | <0.001 | 1.342 (0.719-2.505) | 0.355 |
| M stage, M1 vs. M0 | 909 | 4.327 (2.508-7.465) | <0.001 | 2.677 (1.045-6.858) | 0.04 |
| Pathologic stage, III/IV vs. I/II | 1,041 | 2.519 (1.787-3.549) | <0.001 | 2.041 (0.968-4.302) | 0.061 |
| PR status, positive vs. negative | 1,011 | 0.762 (0.541-1.074) | 0.120 | ||
| ER status, positive vs. negative | 1,014 | 0.704 (0.487-1.017) | 0.062 | 0.402 (0.240-0.674) | <0.001 |
| HER2 status, positive vs. negative | 705 | 1.611 (0.981-2.644) | 0.059 | 0.910 (0.509-1.628) | 0.751 |
| Age, >60 vs. ≤60 years | 1,064 | 2.036 (1.468-2.822) | <0.001 | 3.267 (1.974-5.407) | <0.001 |
| Ethnicity, white vs. Asian/black or African American | 975 | 0.880 (0.593-1.306) | 0.526 | ||
| Histological type, infiltrating ductal carcinoma vs. infiltrating lobular carcinoma | 959 | 1.162 (0.738-1.830) | 0.516 | ||
| Anatomic neoplasm subdivisions, right vs. left | 1,064 | 0.776 (0.559-1.077) | 0.13 | ||
| TP53 status, Mut vs. WT | 955 | 1.218 (0.858-1.730) | 0.269 | ||
| PIK3CA status, Mut vs. WT | 955 | 1.015 (0.696-1.479) | 0.938 | ||
| KRT15, high vs. low | 1,064 | 0.581 (0.417-0.809) | 0.001 | 0.590 (0.358-0.974) | 0.039 |
PR, progesterone receptor; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; WT, wild-type; Mut, mutated; TP53, tumor protein 53; PIK3CA, phosphotidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α; KRT15, keratin 15.