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. 2021 Jan 27;21(4):289. doi: 10.3892/etm.2021.9720

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PDGF-C reverses the inhibitory effects of PAA on the expression of extracellular matrix proteins and cell proliferation in NRK-49F cells. (A) Effects of PDGF-C on the expression of E-cadherin, collagen I, collagen IV, α-SMA and fibronectin in PAA- and/or TGF-β1-treated cells were examined by western blotting. (B) PDGF-C reversed the inhibitory effects of PAA on NRK-49F cell proliferation according to 5-ethynyl-2'-deoxyuridine staining. n=3. ^*P<0.05, ^**P<0.01 and ^***P<0.001. Magnification x40. PAA, poricoic acid A; TGF-β1, transforming growth factor-β1; PDGF-C, platelet-derived growth factor C; α-SMA, α-smooth muscle actin.