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LβH domain creates a tunnel for acetyl-CoA binding. (A) Surface view of ApmA-acetyl-CoA complex superimposed on ApmA-apramycin complex. Chains are colored red, green, and blue. Apramycin and acetyl-CoA are shown in sticks. (B) Active site of superimposed ApmA substrate complexes highlighting residues suspected to be involved in apramycin binding and acetylation.
