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. 2021 Feb 15;11:39. doi: 10.1186/s13578-021-00549-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Life process and differentiation of malignant cells in male and female PTC. a Pseudotime plot of total epithelial cell clusters of males and females with PTC, analyzed by Monocle. b Cluster analysis showing the gene expression profiles of total epithelial cells at different differentiation states. c Pseudotime plot of clusters 13 and 31 (Shown in Fig. 1a). Cells from male and female patients with PTC were labeled with different colors. d The heat map of Top100 gene with significant difference between state 6 and state 7. e The heat map of Top100 gene with significant difference between state 1 and state 2. f The pathway enrichment of state 6. g The pathway enrichment of state 7