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Somatic alterations in DDR pathway. a Frequency of altered pathway for DDR. b Distribution of somatic alterations in specific DDR gene of UTUC and UCB samples. c The distribution of known or likely deleterious somatic DDR gene mutations. DDR: DNA damage repair; UCB: bladder carcinoma; UTUC: upper tract urothelial carcinoma; FA: Fanconi anemia; HR: homologous recombination repair; CP: checkpoint; MMR: mismatch repair; NER: nucleotide excision repair
