Table 1. Stoichiometry (N) and dissociation constant (Kd) obtained by ITC for the binding of nTBP-CTPR2n proteins to hTNKS2 ARC4. For each protein, the values listed are from two independent experiments.
Protein | Stoichiometry (N) | K d (μM) |
1TBP-CTPR2 | 1.01 ± 0.03 | 14.68 ± 0.99 |
0.90 ± 0.02 | 12.80 ± 1.10 | |
2TBP-CTPR4 | 2.18 ± 0.02 | 11.89 ± 0.26 |
2.05 ± 0.01 | 18.59 ± 0.39 | |
3TBP-CTPR6 | 2.72 ± 0.03 | 5.62 ± 0.21 |
2.77 ± 0.02 | 20.12 ± 0.39 | |
4TBP-CTPR8 | 3.38 ± 0.01 | 13.61 ± 0.19 |
2.91 ± 0.03 | 15.48 ± 0.43 |