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. 2021 Feb 2;11:628804. doi: 10.3389/fimmu.2020.628804

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Copyright © 2021 Kulappu Arachchige, Young, Kanci Condello, Omotainse, Noormohammadi, Wawegama and Browning

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reactome pathways enriched with up-regulated genes in the challenged-only group compared to the negative control, vaccinated-and-challenged or vaccinated-only group. (A) Pathways involved in DNA replication, (B) other pathways, (C) pathways involved in the cell cycle (mitosis), (D) pathways involved in immune responses, (E) pathways involved in signal transduction. Grey solid circles indicate the proportion of up-regulated genes out of the total number of genes in each pathway. The pathways are listed in order of decreasing proportions in the negative control group. A false discovery rate (FDR) of < 0.01 was considered significant.