Table 1.
Log2 fold changes (FC) and false discovery rates (FDR) of the up-regulated genes among the 25 most differentially expressed genes based on FDR in the challenged-only group compared to the other groups.
| Gene name | Challenged-only group compared to: | |||||
|---|---|---|---|---|---|---|
| Negative control | Vaccinated-and-challenged | Vaccinated-only | ||||
| FC | FDR | FC | FDR | FC | FDR | |
| DNA replication and cell cycle | ||||||
| Cell division cycle associated 3 | 5.931 | 6.49E-06 | 5.673 | 6.57E-06 | 6.045 | 5.57E-06 |
| Sperm associated antigen 5 | 5.362 | 6.49E-06 | 5.246 | 9.89E-06 | 5.840 | 5.63E-06 |
| Ubiquitin conjugating enzyme E2 C | 5.274 | 6.49E-06 | 4.613 | 8.70E-06 | 5.448 | 5.48E-06 |
| Karyopherin subunit alpha 2 | 4.866 | 5.03E-06 | 4.774 | 4.22E-06 | 4.863 | 4.49E-06 |
| Minichromosome maintenance complex component 5 | 4.480 | 6.49E-06 | 4.304 | 8.70E-06 | 4.654 | 5.57E-06 |
| Thymidine kinase 1 | 5.280 | 6.49E-06 | 6.243 | 5.73E-06 | ||
| Topoisomerase (dna) II alpha | 4.792 | 6.72E-06 | 5.400 | 5.73E-06 | ||
| Cyclin B3 | 4.842 | 7.46E-06 | ||||
| Myb proto-oncogene-like 2 | 4.260 | 6.72E-06 | ||||
| Cyclin B1 | 4.133 | 6.49E-06 | ||||
| Minichromosome maintenance complex component 2 | 3.770 | 9.19E-06 | ||||
| Ribonucleotide reductase regulatory subunit m2 | 6.196 | 6.49E-06 | ||||
| Prevention of apoptosis | ||||||
| Thioredoxin domain containing 5 | 4.476 | 8.93E-08 | 4.371 | 1.50E-07 | 4.291 | 1.81E-07 |
| Other | ||||||
| Matrix metallopeptidase 7 | 9.003 | 6.12E-06 | 7.630 | 3.51E-06 | 9.789 | 5.63E-06 |
| Biliverdin reductase A | 5.808 | 8.52E-06 | ||||
| Derlin 3 | 3.006 | 6.49E-06 | ||||
A false discovery rate (FDR) of < 0.01 was considered significant.