Table 2.
Log2 fold changes (FC) and false discovery rates (FDR) of the down-regulated genes among the 25 most differentially expressed genes based on FDR in the challenged-only group compared to the other groups.
| Gene name | Challenged-only group compared to: | |||||
|---|---|---|---|---|---|---|
| Negative control | Vaccinated-and-challenged | Vaccinated-only | ||||
| FC | FDR | FC | FDR | FC | FDR | |
| Assembly and motor movement of cilia | ||||||
| Parkin coregulated | −7.674 | 5.03E-06 | −8.529 | 1.99E-06 | −8.416 | 2.14E-06 |
| PIH1 domain containing 3 | −5.313 | 5.03E-06 | −5.713 | 2.04E-06 | −5.695 | 2.14E-06 |
| UBX domain protein 10 | −4.678 | 6.49E-06 | −4.999 | 3.51E-06 | −4.969 | 4.49E-06 |
| Enkurin, TRPC channel interacting protein | −6.618 | 4.22E-06 | −6.292 | 5.63E-06 | ||
| Doublecortin domain-containing 2B | −5.470 | 6.57E-06 | −5.544 | 5.57E-06 | ||
| Dynein assembly factor with WD repeats 1 | −5.272 | 8.16E-06 | −5.379 | 5.63E-06 | ||
| Oxidoreductase activity | ||||||
| Glutathione S-transferase omega 2 | −3.523 | 3.51E-06 | −3.670 | 3.46E-06 | ||
| Peroxiredoxin 6 | −3.073 | 3.51E-06 | −2.789 | 5.57E-06 | ||
| Aldo-keto reductase family 1, member B1-like | −3.843 | 1.01E-05 | ||||
| Cytochrome P450 2G1-like | −5.914 | 6.49E-06 | ||||
| Metabolism | ||||||
| Adenylate kinase 8 | −7.045 | 5.93E-06 | −7.227 | 5.17E-06 | ||
| Serine/threonine/tyrosine interacting-like 1 | −5.694 | 4.22E-06 | −5.782 | 4.49E-06 | ||
| Other | ||||||
| EF-hand calcium binding domain 10 | −5.329 | 6.49E-06 | −5.930 | 3.51E-06 | −6.012 | 3.46E-06 |
| Coiled-coil domain containing 27 | −5.259 | 6.49E-06 | −5.787 | 3.51E-06 | −5.931 | 3.46E-06 |
| Chromosome 11 open reading frame 88 | −8.748 | 1.01E-05 | −8.924 | 7.17E-06 | ||
| MORN repeat containing 3 | −5.808 | 7.28E-06 | −5.860 | 5.63E-06 | ||
| Chromosome 9 open reading frame 116 | −5.171 | 3.51E-06 | −5.056 | 4.49E-06 | ||
| Transmembrane protein 68-like | −6.727 | 6.49E-06 | −6.482 | 6.66E-06 | ||
| Uncharacterized loc107050476 | −4.878 | 6.49E-06 | −4.728 | 8.16E-06 | ||
| Aquaporin 5 | −4.603 | 9.19E-06 | ||||
| Chromosome 3 open reading frame 67 | −6.029 | 1.03E-05 | ||||
A false discovery rate (FDR) of < 0.01 was considered significant.