Table 3.
Log2 fold changes (FC) and false discovery rates (FDR) of differentially expressed genes for cytokines, chemokines and their receptors in the challenged-only group compared to the other groups.
| Gene name | Challenged-only group compared to: | |||||
|---|---|---|---|---|---|---|
| Negative control | Vaccinated-and-challenged | Vaccinated-only | ||||
| FC | FDR | FC | FDR | FC | FDR | |
| Cytokines | ||||||
| Interleukin-4 induced 1 | 7.686 | 2.77E-04 | 7.712 | 5.19E-04 | 7.27 | 3.40E-04 |
| Interferon gamma | 5.982 | 1.87E-04 | 6.049 | 3.18E-04 | 6.918 | 1.83E-04 |
| Interleukin-22 | 5.109 | 3.23E-03 | ||||
| Interleukin-16 | 3.438 | 2.53E-03 | 3.545 | 2.87E-03 | ||
| Chemokines | ||||||
| C-C motif chemokine ligand 26 | 6.703 | 1.08E-05 | 6.378 | 2.08E-05 | 6.289 | 1.38E-05 |
| C-C motif chemokine ligand 19 | 5.193 | 9.54E-05 | 5.635 | 1.50E-04 | 5.269 | 1.23E-04 |
| C-X-C motif chemokine ligand 13-like 3 | 5.196 | 6.51E-04 | 4.23 | 2.59E-03 | 5.681 | 6.34E-04 |
| C-X-C motif chemokine ligand 13 | 5.453 | 8.57E-04 | 5.161 | 1.72E-03 | 5.751 | 9.87E-04 |
| C-X-C motif chemokine ligand 13-like 2 | 7.313 | 3.26E-03 | 7.307 | 5.67E-03 | 6.725 | 4.42E-03 |
| Chemokine ah221 | 4.412 | 2.97E-03 | 3.996 | 7.05E-03 | 5.232 | 2.02E-03 |
| C-C motif chemokine ligand 4 (MIP-1β) | 3.23 | 5.87E-03 | 4.108 | 2.40E-03 | ||
| C-X-C motif chemokine ligand 12 | 2.49 | 2.88E-03 | 2.253 | 8.76E-03 | ||
| X-C motif chemokine ligand 1 | 3.956 | 9.41E-03 | 4.934 | 5.32E-03 | ||
| Chemokine (C-X-C motif) ligand 1-like | 5.079 | 2.80E-03 | ||||
| C-C motif chemokine ligand 20 | −3.903 | 9.76E-03 | ||||
| Cytokine receptors | ||||||
| Interleukin-2 receptor subunit gamma | 5.084 | 9.19E-06 | 4.449 | 2.24E-05 | 4.772 | 1.28E-05 |
| Interleukin-12 receptor subunit beta 1 | 6.604 | 2.74E-04 | 5.647 | 8.08E-04 | 5.852 | 5.20E-04 |
| Interleukin-21 receptor | 4.736 | 9.26E-04 | 4.145 | 2.86E-03 | 4.684 | 1.25E-03 |
| Interleukin-20 receptor subunit alpha | 3.236 | 6.20E-04 | 2.844 | 2.57E-03 | 3.187 | 8.23E-04 |
| Interleukin-13 receptor subunit alpha 2 | 4.778 | 2.18E-03 | 3.899 | 7.70E-03 | 4.845 | 3.07E-03 |
| Interleukin-7 receptor | 2.71 | 9.87E-03 | 3.113 | 6.97E-03 | 2.925 | 7.61E-03 |
| Interleukin-10 receptor subunit alpha | 2.64 | 4.56E-03 | 3.017 | 2.87E-03 | 2.832 | 3.52E-03 |
| Colony stimulating factor 3 receptor | 3.89 | 2.66E-04 | 3.474 | 8.88E-04 | 3.595 | 5.05E-04 |
| TNF receptor superfamily member 13B | 5.724 | 1.22E-04 | 4.846 | 3.22E-04 | 4.852 | 2.38E-04 |
| Granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like | 3.56 | 1.34E-03 | 3.583 | 2.43E-03 | 3.169 | 3.54E-03 |
| Colony stimulating factor 2 receptor beta common subunit | 3.166 | 5.23E-03 | 3.487 | 3.97E-03 | 3.727 | 2.46E-03 |
| TNF receptor superfamily member 1B | 2.853 | 3.85E-03 | 2.697 | 9.67E-03 | 2.918 | 4.36E-03 |
| Cytokine receptor like factor 3 | 2.235 | 5.10E-03 | 2.327 | 6.03E-03 | ||
| Interleukin 1 receptor-like 2 | −2.439 | 2.35E-03 | −2.19 | 9.04E-03 | ||
| TNF receptor superfamily member 4 | 3.418 | 2.13E-03 | 2.889 | 7.83E-03 | ||
| Interleukin 1 receptor associated kinase 1 binding protein 1 | −2.765 | 6.43E-04 | −2.73 | 6.28E-04 | ||
| Cytokine receptor common subunit beta-like | 3.291 | 6.79E-03 | ||||
| Chemokine receptors | ||||||
| C-X-C chemokine receptor type 3-like | −3.403 | 2.21E-04 | −3.169 | 5.74E-04 | −3.827 | 6.99E-05 |
| X-C motif chemokine receptor 1 | 5.757 | 3.78E-04 | 5.4 | 6.67E-04 | 5.144 | 6.74E-04 |
| C-C motif chemokine receptor 10 | 7.524 | 8.90E-05 | 6.273 | 1.50E-04 | 6.423 | 1.15E-04 |
| C-X-C motif chemokine receptor 5 | 3.951 | 4.18E-03 | 5.012 | 3.10E-03 | 4.68 | 2.67E-03 |
| C-X-C motif chemokine receptor 4 | 3.183 | 5.19E-04 | 3.813 | 3.46E-04 | 3.212 | 6.27E-04 |
| C-X3-C motif chemokine receptor 1 | 4.414 | 2.13E-03 | 3.572 | 9.53E-03 | 3.909 | 4.68E-03 |
| C-C motif chemokine receptor 2 | 2.936 | 6.70E-03 | 3.911 | 2.60E-03 | ||
| C-C motif chemokine receptor 5 | 6.12 | 4.71E-05 | 5.555 | 1.04E-04 | ||
A false discovery rate (FDR) of < 0.01 was considered significant.