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. 2021 Feb 2;11:628804. doi: 10.3389/fimmu.2020.628804

Table 4.

Log2 fold changes (FC) and false discovery rates (FDR) of differentially expressed MHC and other immune response-related genes in the challenged-only group compared to the other groups.

Gene name Challenged-only group compared to:
Negative control Vaccinated-and-challenged Vaccinated-only
FC FDR FC FDR FC FDR
MHC antigen-related genes
Major histocompatibility complex, class II, DM alpha 4.083 4.46E-05 2.507 1.94E-03 3.402 1.48E-04
Major histocompatibility complex class I antigen BF2 2.605 6.78E-04 2.298 3.10E-03 2.6 7.01E-04
Major histocompatibility complex, class II, DM beta 2 4.015 2.50E-04 2.842 3.51E-03 3.087 1.40E-03
Major histocompatibility complex class II beta chain BLB2 2.824 8.01E-04 2.591 2.03E-03
Major histocompatibility complex class II beta chain BLB1 3.544 3.12E-03 3.319 5.93E-03
Major histocompatibility complex, class II, DM beta 1 5.857 2.08E-04 3.321 4.18E-03
Major histocompatibility complex, class I, A6 2.183 1.25E-03
Immunoglobulin-related genes
Fc receptor-like protein 3-like 4.575 4.10E-04 4.637 6.61E-04 6.047 2.07E-04
V-set and immunoglobulin domain containing 4 2.717 3.01E-03 2.551 7.70E-03
Immunoglobulin superfamily member 1-like 6 1.37E-03 4.617 6.14E-03
Immunoglobulin superfamily member 1 3.634 4.22E-03
Osteoclast-associated immunoglobulin-like receptor-like 3.68 6.47E-03
Osteoclast-associated immunoglobulin-like receptor 3.719 8.74E-03
Fc fragment of IgE receptor Ig 4.237 8.44E-03
Immunoglobulin-like receptor CHIR-B3 3.568 9.53E-03
Toll-like receptors
Toll-like receptor 7 4.904 1.06E-03 4.306 3.40E-03 4.463 1.93E-03
Toll-like receptor 2 family member B 5.489 2.59E-03 5.295 4.82E-03 4.56 6.14E-03
Toll-like receptor 1 family member A 3.406 3.42E-03 3.597 4.83E-03 5.117 7.89E-04
Toll-like receptor 5 −2.747 3.54E-03
Complement-related genes
Complement C3a receptor 1 3.713 6.51E-04 4.005 9.40E-04 3.136 2.33E-03
Complement C1s 2.761 8.30E-04 2.913 8.11E-04 2.806 8.26E-04
Complement C1q A chain 3.028 1.53E-03 2.547 8.67E-03 2.761 3.83E-03
Complement component 3 1.869 4.94E-03 2.063 2.06E-03 2.566 1.61E-04
Complement 4 2.554 5.74E-03 2.555 8.69E-03 2.578 6.80E-03
Complement C1q C chain 3.131 2.14E-03 2.624 9.25E-03
Complement C1q B chain 3.52 3.27E-03
Complement C1q binding protein 1.755 1.23E-03
Complement component 4 2.098 8.14E-03
Complement C7         3.353 9.07E-03

A false discovery rate (FDR) of < 0.01 was considered significant.