TABLE 1.
HuNoV strains tested for cultivation in jejunal HIEs cultured in BCM medium
| Reference strain | Age (y or m)a | Titer (GEs/μl) | Log10 increase in viral RNA in BCM medium |
|---|---|---|---|
| GI.1[P1]/1968/Norwalk | NA | 5.7 × 106 | 0.5 |
| GI.3/TCH14-184 | NA | 1.0 × 104 | 0.0 |
| GII.1/TCH18-98 | 23 m | 1.8 × 104 | 0.5 |
| GII.2[P2]/TCH05-951 | NA | 1.7 × 106 | 0.7 |
| GII.3[P21]/TCH04-577 | 7 y | 8.5 × 106 | 1.6 |
| GII.4 Farmington Hills[P4]/TCH03-151 | 16 m | 1.6 × 102 | 0.0 |
| GII.4 Yerseke[P4]/TCH02-186 | 2 m | 2.3 × 106 | 1.5 |
| GII.4 Yerseke/TCH02-276 | 10 m | 1.6 × 105 | 0.8 |
| GII.4 Yerseke[P4]/TCH07-194 | 7 m | 7.0 × 107 | 1.6 |
| GII.4 Den Haag[P4]/TCH07-348 | 6 m | 1.5 × 105 | 0.0 |
| GII.4 Den Haag[P4]/TCH07-882 | 5 y | 1.5 × 107 | 1.8 |
| GII.4 Den Haag/TCH08-135 | 3 y | 6.8 × 106 | 0.0 |
| GII.4 Den Haag[P4]/TCH08-227 | 2.5 y | 5.3 × 106 | 1.5 |
| GII.4 Den Haag[P4]/TCH08-429 | 8 y | 3.0 × 104 | 1.3 |
| GII.4 Den Haag[P4]/TCH08-430 | 8 y | 6.2 × 104 | 0.9 |
| GII.4 Den Haag[P4]/MDA09-01 | NA | 1.1 × 107 | 1.6 |
| GII.4 New Orleans[P4]/TCH09-935 | 13 y | 2.3 × 105 | 0.0 |
| GII.4 New Orleans[P4]/TCH10-52 | 19 y | 1.2 × 107 | 0.0 |
| GII.4 New Orleans[P4]/TCH11-64 | 12 m | 3.0 × 107 | 1.6 |
| GII.4 Sydney[P31]/TCH12-556 | 15 y | 2.2 × 102 | 0.0 |
| GII.4 Sydney[P31]/TCH12-580 | 17 m | 1.8 × 107 | 2.3 |
| GII.4 Sydney[P31]/TCH13-196 | 10 y | 4.3 × 104 | 0.0 |
| GII.4 Sydney[P31]/TCH13-601 | 15 m | 7.1 × 104 | 0.0 |
| GII.4 Sydney[P31]/TCH14-10 | 11 m | 3.0 × 106 | 2.0 |
| GII.4 Sydney/TCH15-82 | 5 y | 4.4 × 105 | 2.2 |
| GII.4 Sydney[P31]/TCH15-88 | 5 y | 1.4 × 105 | 3.0 |
| GII.4 Sydney[P16]/TCH15-123 | 2.5 y | 3.2 × 105 | 2.0 |
| GII.4 Sydney[P31]/BCM16-1 | NA | 1.0 × 107 | 1.6 |
| GII.4 Sydney[P16]/BCM16-16 | 4 y | 1.0 × 107 | 1.8 |
| GII.4 Sydney[P16]/BCM16-22 | 15 m | 1.0 × 107 | 1.8 |
| GII.6[P7]/TCH08-166 | 6 m | 4.5 × 106 | 1.0 |
| GII.6[P7]/TCH13-106 | 7 y | 6.6 × 105 | 0.8 |
| GII.6[P7]/TCH15-167 | 9 y | 4.5 × 106 | 2.0 |
| GII.7[P7]/TCH06-163 | 21 m | 6.3 × 105 | 0.5 |
| GII.8[P8]/TCH09-279 | 4 y | 1.6 × 105 | 0.5 |
| GII.12/TCH09-477 | 5 y | 2.6 × 105 | 0.8 |
| GII.13/TCH10-338 | NA | 1.0 × 105 | 0.5 |
| GII.14[P7]/TCH14-364 | 20 y | 1.3 × 105 | 0.5 |
| GII.17[P38]/TCH14-385 | 9 y | 1.4 × 107 | 0.5 |
| GII.17[P13]/1295-44 | NA | 9.3 × 106 | 0.7 |
a
y, years; m, months. NA, not available. All infections were done in the presence of GCDCA.