TABLE 2.
HuNoV strains successfully replicated in jejunal HIEs plated in BCM versus INT medium
| Reference strain | Titer (GEs/μl) | Log10 increase in viral RNA in BCM medium | Log10 increase in viral RNA in INT medium |
|---|---|---|---|
| GI.1[P1]/1968/Norwalk | 5.7 × 106 | 0.5 | 1.9a |
| GI.3/TCH14-184 | 1.0 × 104 | 0.0 | 0.0 |
| GII.1/TCH18-98 | 1.8 × 104 | 0.5 | 1.7a |
| GII.2[P2]/TCH05-951 | 1.7 × 106 | 0.7 | 2.1a |
| GII.3[P21]/TCH04-577 | 8.5 × 106 | 1.6 | 2.1a |
| GII.4 Yerseke[P4]/TCH07-194 | 7.0 × 107 | 1.5 | 2.0a |
| GII.4 Den Haag[P4]/TCH07-882 | 1.5 × 107 | 1.8 | 2.2a |
| GII.4 Den Haag[P4]/MDA09-01 | 1.1 × 107 | 1.6 | 2.4a |
| GII.4 New Orleans[P4]/TCH11-64 | 3.0 × 107 | 1.6 | 1.7 |
| GII.4 Sydney[P31]/TCH12-580 | 1.8 × 107 | 2.3 | 2.7a |
| GII.4 Sydney/TCH15-82 | 4.4 × 105 | 2.2 | 2.8a |
| GII.4 Sydney[P31]/BCM16-1 | 1.0 × 107 | 1.6 | 2.0a |
| GII.4 Sydney[P16]/BCM16-16 | 1.0 × 107 | 1.8 | 2.2a |
| GII.6[P7]/TCH13-106 | 6.6 × 105 | 0.8 | 1.3a |
| GII.6[P7]/TCH15-167 | 4.5 × 106 | 2.0 | 2.9a |
| GII.8[P8]/TCH09-279 | 1.6 × 105 | 0.5 | 0.7a |
| GII.12/TCH09-477 | 2.6 × 105 | 0.8 | 1.1 |
| GII.13/TCH10-338 | 1.0 × 105 | 0.5 | 0.9a |
| GII.14[P7]/TCH14-364 | 1.3 × 105 | 0.5 | 1.5a |
| GII.17[P38]/TCH14-385 | 1.4 × 107 | 0.5 | 2.1a |
| GII.17[P13]/1295-44 | 9.3 × 106 | 0.7 | 1.5a |
a
Significant increase in INT versus BCM medium. All infections were done in the presence of GCDCA.