Table 3.
SNPs included in the analysis and association with malaria infection
| Gene | SNPs | Alleles or genotypes | Model | Univariate analysis | Multivariate analysisa | ||
|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | AOR (95%CI) | P | ||||
| Allele-based analysis | |||||||
| TLR1 | rs4833095 | T vs C | – | 0.80 (0.51–1.24) | 0.318 | 0.89 (0.54–1.47) | 0.660 |
| TLR4 | rs4986790 | G vs A | – | 1.15 (0.70–1.88) | 0.581 | 1.44 (0.82–2.53) | 0.204 |
| TLR9 | rs5743836 | G vs A | – | 1.01 (0.76–1.32) | 0.972 | 0.98 (0.72–1.33) | 0.760 |
| TLR9 | rs352139 | T vs C | – | 1.13 (0.85–1.49) | 0.384 | 1.22 (0.89–1.66) | 0.219 |
| IL-4 | rs2243250 | C vs T | – | 0.91 (0.66–1.27) | 0.606 | 0.89 (0.63–1.27) | 0.534 |
| IL-10 | rs1800896 | C vs T | – | 1.07 (0.78–1.46) | 0.664 | 1.07 (0.76–1.53) | 0.685 |
| IL-10 | rs1800890 | T vs A | – | 1.04 (0.73–1.46) | 0.835 | 1.10 (0.75–1.61) | 0.614 |
| IL-17F | rs4715291 | T vs C | – | 1.23 (0.83–1.82) | 0.305 | 1.11 (0.72–1.71) | 0.629 |
| IL-1β | rs1143634 | A vs G | – | 0.58 (0.40–0.86) | 0.006 | 0.52 (0.34–0.80) | 0.003 |
| TNF-α | rs1800629 | A vs G | – | 0.86 (0.59–1.26) | 0.444 | 0.91 (0.60–1.38) | 0.669 |
| TNF-α | rs3093664 | G vs A | – | 0.88 (0.50–1.56) | 0.663 | 0.93 (0.48–1.78) | 0.826 |
| IFNR1 | rs10213701 | A vs T | – | 1.02 (0.77–1.35) | 0.891 | 0.97 (0.71–1.34) | 0.888 |
| IFNR1 | rs10065633 | C vs T | – | 1.12 (0.84–1.47) | 0.407 | 1.20 (0.88–1.63) | 0.238 |
| NOS2A | rs2297518 | A vs G | – | 1.32 (0.77–2.26) | 0.306 | 1.28 (0.71–2.33) | 0.408 |
| FcγRIIA/CD32 | rs1801274 | A vs G | – | 0.62 (0.47–0.82) | < 0.001 | 0.51 (0.37–0.70) | < 0.001 |
| Genotype-based analysisb | |||||||
| TLR1 | rs4833095 | TT vs TC/CC | Recessive | 0.60 (0.11–3.14) | 0.423 | 0.57 (0.10–3.18) | 0.521 |
| TLR4 | rs4986790 | GA/GG vs AA | Dominant | 1.11 (0.66–1.86) | 0.828 | 1.43 (0.79–2.58) | 0.237 |
| TLR9 | rs5743836 | GG vs GA/AA | Recessive | 0.87 (0.54–1.40) | 0.565 | 0.95 (0.56–1.62) | 0.861 |
| TLR9 | rs352139 | TT vs TC/CC | Recessive | 1.30 (0.79–2.14) | 0.291 | 1.57 (0.89–2.77) | 0.117 |
| IL-4 | rs2243250 | TC vs TT/CC | Over-dominant | 0.93 (0.62–1.40) | 0.730 | 0.91 (0.58–1.43) | 0.695 |
| IL-10 | rs1800896 | CT vs TT/CC | Over-dominant | 1.32 (0.86–2.02) | 0.201 | 1.60 (0.99–2.61) | 0.057 |
| IL-10 | rs1800890 | TA vs TT/AA | Over-dominant | 1.33 (0.86–2.07) | 0.203 | 1.52 (0.93–2.48) | 0.098 |
| IL-17F | rs4715291 | TT vs TC/CC | Recessive | 1.15 (0.73–1.83) | 0.537 | 1.28 (0.35–4.61) | 0.710 |
| IL-1β | rs1143634 | AG/AA vs GG | Dominant | 0.58 (0.37–0.89) | 0.013 | 0.52 (0.32–0.84) | 0.007 |
| TNF-α | rs1800629 | AA vs GA/GG | Recessive | 1.34 (0.29–6.13) | 0.704 | 1.41 (0.28–7.10) | 0.677 |
| TNF-α | rs3093664 | GA vs GG/AA | Over-dominant | 0.74 (0.41–1.35) | 0.325 | 0.77 (0.39–1.52) | 0.454 |
| IFNR1 | rs10065633 | TC vs CC/TT | Over-dominant | 0.89 (0.61–1.32) | 0.574 | 0.90 (0.58–1.37) | 0.619 |
| IFNR1 | rs10213701 | TA vs AA/TT | Over-dominant | 0.85 (0.58–1.25) | 0.415 | 0.86 (0.56–1.32) | 0.492 |
| NOS2A | rs2297518 | GA/AA vs GG | Over-dominant | 1.32 (0.74–2.34) | 0.342 | 1.30 (0.69–2.46) | 0.421 |
| FcγRIIA/CD32 | rs1801274 | GA/AA vs GG | Dominant | 0.52 (0.34–0.78) | 0.001 | 0.45 (0.28–0.70) | < 0.001 |
Significant P values < 0.05 are indicated in italics
aAdjusted by mother’s age, gravidity, Birth season, baby’s sex, LBW, Prenatal malaria exposure, ethnicity, Haemoglobin variants
bGenotype-based analysis for dominant, over-dominant and recessive models. Models that showed lowest P values are shown