Table 4.
SNPs included in the analysis and association with clinical malaria
| Gene | SNPs | Alleles/genotypes | Model | Univariate analysis | Multivariate analysisa | ||
|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | ||||
| Allele-based analysis | |||||||
| TLR1 | rs4833095 | T vs C | – | 0.90 (0.62–1.33) | 0.608 | 0.96 (0.63–1.46) | 0.844 |
| TLR4 | rs4986790 | G vs A | – | 1.04 (0.70–1.54) | 0.838 | 1.19 (0.76–1.87) | 0.442 |
| TLR9 | rs5743836 | G vs A | – | 0.89 (0.71–1.12) | 0.324 | 0.82 (0.64–1.06) | 0.137 |
| TLR9 | rs352139 | T vs C | – | 1.13 (0.90–1.42) | 0.296 | 1.09 (0.84–1.40) | 0.524 |
| IL-4 | rs2243250 | C vs T | – | 1.04 (0.79–1.36) | 0.772 | 0.97 (0.72–1.31) | 0.857 |
| IL-10 | rs1800896 | C vs T | – | 1.05 (0.82–1.35) | 0.676 | 1.00 (0.76–1.33) | 0.982 |
| IL-10 | rs1800890 | T vs A | – | 1.17 (0.88–1.56) | 0.268 | 1.14 (0.83–1.56) | 0.423 |
| IL-17F | rs4715291 | T vs C | – | 1.12 (0.82–1.53) | 0.462 | 0.98 (0.70–9.07) | 0.918 |
| IL-1β | rs1143634 | A vs G | – | 0.68 (0.48–0.95) | 0.025 | 0.66 (0.46–0.97) | 0.032 |
| TNF-α | rs1800629 | A vs G | – | 0.97 (0.70–1.33) | 0.843 | 1.08 (0.76–1.53) | 0.682 |
| TNF-α | rs3093664 | G vs A | – | 0.82 (0.51–1.32) | 0.406 | 0.73 (0.43–1.25) | 0.259 |
| IFNR1 | rs10213701 | A vs T | – | 1.11 (0.88–1.41) | 0.361 | 1.15 (0.89–1.50) | 0.283 |
| IFNR1 | rs10065633 | C vs T | – | 1.02 (0.82–0.82) | 0.843 | 1.06 (0.82–1.36) | 0.644 |
| NOS2A | rs2297518 | A vs G | – | 1.09 (0.72–1.65) | 0.682 | 1.32 (0.83–2.10) | 0.239 |
| FcγRIIA/CD32 | rs1801274 | A vs G | – | 0.71 (0.56–0.90) | 0.005 | 0.68 (0.52–0.89) | 0.005 |
| Genotype-based analysisb | |||||||
| TLR1 | rs4833095 | TT vs TC/CC | Recessive | 0.44 (0.10–1.99) | 0.286 | 0.50 (0.11–2.36) | 0.388 |
| TLR4 | rs4986790 | GA/GG vs AA | Dominant | 1.02 (0.67–1.56) | 0.910 | 1.28 (0.79–2.06) | 0.313 |
| TLR9 | rs5743836 | GG vs GA/AA | Recessive | 0.81 (0.54–1.20) | 0.295 | 0.77 (0.50–1.20) | 0.250 |
| TLR9 | rs352139 | TT vs TC/CC | Recessive | 1.33 (0.90–1.98) | 0.155 | 1.33 (0.86–2.06) | 0.197 |
| IL-4 | rs2243250 | TC vs TT/CC | Over-dominant | 0.96 (0.68–1.35) | 0.818 | 0.83 (0.57–1.20) | 0.326 |
| IL-10 | rs1800896 | CT vs TT/CC | Over-dominant | 1.07 (0.76–1.50) | 0.690 | 1.29 (0.88–1.88) | 0.185 |
| IL-10 | rs1800890 | TA vs TT/AA | Over-dominant | 1.41 (0.99–2.01) | 0.059 | 1.48 (0.99–2.19) | 0.052 |
| IL-17F | rs4715291 | TT vs TC/CC | Recessive | 1.29 (0.52–3.02) | 0.583 | 0.92 (0.35–2.46) | 0.882 |
| IL-1β | rs1143634 | AA vs AG/GG | Recessive | 0.29 (0.07–1.18) | 0.086 | 0.14 (0.03–0.78) | 0.024 |
| TNF-α | rs1800629 | AA vs GA/GG | Recessive | 1.34 (0.41–4.41) | 0.626 | 2.15 (0.54–8.59) | 0.279 |
| TNF-α | rs3093664 | GA vs GG/AA | Over-dominant | 0.85 (0.50–1.42) | 0.529 | 0.70 (0.40–1.25) | 0.230 |
| IFNR1 | rs10065633 | TC vs CC/TT | Over-dominant | 1.03 (0.75–1.41) | 0.869 | 1.14 (0.80–1.61) | 0.476 |
| IFNR1 | rs10213701 | TA/AA vs TT | Dominant | 1.13 (0.82–1.55) | 0.468 | 1.20 (0.84–1.70) | 0.331 |
| NOS2A | rs2297518 | GA/AA vs GG | Dominant | 1.11 (0.71–1.73) | 0.656 | 1.30 (0.79–2.14) | 0.307 |
| FcγRIIA/CD32 | rs1801274 | GA/AA vs GG | Dominant | 0.65 (0.47–0.89) | 0.008 | 0.58 (0.41–0.84) | 0.003 |
Significant P values < 0.05 are indicated in italics
aAdjusted by mother’s age, gravidity, birth season, baby’s gender, low birth weight, Prenatal malaria exposure, ethnicity, Haemoglobin variant
bGenotype-based analysis for dominant, over-dominant and recessive models. Models that showed lowest P values (P) are shown