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. 2021 Feb 16;16:139. doi: 10.1186/s13018-021-02281-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — (a) Radiological analysis of the knee joint after treatment with the silk-collagen scaffold (S) and HA/silk-collagen scaffold (HA). (b) Gross observation of the cartilage surface of the femoral condyles stained with India ink to show the defects. (c) HE staining and (d) Safranin O staining of the cartilage surface of the femoral condyles. (e) Histological evaluation according to the Mankin scoring system. Asterisk indicates a significant difference between groups