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. 2021 Feb 15;19:3. doi: 10.1186/s12953-021-00171-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Quantitative proteomic comparison of CVF between PTB and control group. a Venn diagram illustrating the overlap of protein quantified in PTB (Experiment 1) and control (Experiment 2) group. b The box plot of normalized log₂ iTRAQ ratios for PTB group versus pooled control (115/114, 116/114, 117/114, 118/114, 119/114 and 121/114) and control group versus pooled control (113/121, 114/121, 115/121, 116/121, 117/121, 118/121 and 119/121). A line across the box represents the median and outliers correspond to log₂ values greater than 0.58 or less than − 0.58. PP, pooled PTB; P, PTB; C, control c The histogram distribution of normalized log₂ iTRAQ ratio between pooled PTB and pooled control d A volcano plot of significantly changed proteins between PTB and control group. A plot is constructed from log₂ fold-change (x-axis) and – log Benjamini-Hochberg adjust p-value (y-axis) for iTRAQ data of PTB and control group. The threshold for determining significantly differential expression is indicated by dashed lines (adjust p-value < 0.05, fold-change > 1.5). Dots selected in red indicate significantly up- and down-regulated proteins