Fig. 5.

Histone-modification correlates of RNA stability. a ChIP-seq signal for H3K79me2 (left), H3K4me1 (middle), and H3K4me2 (right) for low-, medium-, and high-stability mRNAs (see the “Methods” section ) as a function of distance from the TSS. Results are for intron-containing mRNAs matched by normalized PRO-seq signal. Solid line represents mean signal and lighter shading represents standard error and 95% confidence interval. b Estimated SEM coefficients for half-life (μ_n) for 11 histone modifications, as assayed by ChIP-seq in the 500 bases immediately downstream of the TSS, also for intron-containing mRNAs (see the “Methods” section; see Additional file 2: Figures S28-S30 for additional results). Error bars and significance are as in Fig. 3b