Table 3.
Associations between time to culture conversion, IFN-γ response, and selected clinical parameters.
| Parameter | Timepoint | Descriptive analysis (n = 108) | Univariate analysis | Multivariate analysis1 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Slow responders (n = 16; reference) | Fast responders (n = 92) | P | OR (95%CI) | p | aOR (95%CI) | p | C | AIC | ||
| MIT IFN-γ (IU/ml) | T0 | 4.9 (1.8–10) | 10 (9.82–10) | 0.0028 | 0.78 (0.67–0.91) | 0.001 | 0.65 (0.44–0.86) | 0.009 | 0.75 | 57.5 |
| T1 | 8.3 (3.9–10) | 10 (9.93–10) | 0.0039 | 0.84 (0.72–0.98) | 0.021 | 0.77 (0.56–1.01) | 0.076 | 0.68 | 63.9 | |
| T2 | 9.4 (4.8–10) | 10 (9.94–10) | 0.023 | 0.88 (0.76–1.04) | 0.11 | 0.78 (0.57–1.05) | 0.10 | 0.66 | 64.7 | |
| Positive QFT-P IGRA | T0 | 25% (4/16) | 63% (58/92) | 0.006 | 0.19 (0.051–0.61) | 0.008 | 0.045 (0.002–0.35) | 0.013 | 0.77 | 57.6 |
| T1 | 31.2% (5/16) | 56.5% (52/92) | 0.10 | 0.33 (0.099–0.99) | 0.059 | 0.39 (0.064–1.97) | 0.27 | 0.64 | 66.2 | |
| T2 | 50% (8/16) | 53.3% (49/92) | 0.98 | 0.88 (0.29–2.57) | 0.81 | 3.27 (0.59–24.1) | 0.20 | 0.65 | 65.7 | |
| Positive HBHA IGRA | T0 | 25% (4/16) | 35.9% (33/92) | 0.57 | 0.62 (0.16–1.96) | 0.44 | 0.39 (0.075–1.71) | 0.24 | 0.64 | 66.7 |
| T1 | 31.2% (5/16) | 65.2% (60/92) | 0.013 | 0.24 (0.071–0.73) | 0.015 | 0.076 (0.003–0.67) | 0.045 | 0.74 | 61.9 | |
| T2 | 50% (8/16) | 77.2% (71/92) | 0.033 | 0.29 (0.097–0.89) | 0.029 | 0.79 (0.17–4.13) | 0.77 | 0.61 | 67.1 | |
| Lymphocyte % of WBC | T0 | 17.5 (12.8–19.5) | 19.0 (15–26) | 0.099 | 0.93 (0.84–1.00) | 0.086 | 0.94 (0.83–1.05) | 0.33 | 0.64 | 66.4 |
| T1 | 23.0 (16.2–28.0) | 25.0 (20.7–31) | 0.099 | 0.93 (0.86–0.99) | 0.052 | 0.92 (0.83–0.99) | 0.078 | 0.68 | 63.3 | |
| T2 | 29.5 (23.5–36.2) | 30.0 (25.9–36) | 0.93 | 1.01 (0.95–1.06) | 0.76 | 1.01 (0.94–1.08) | 0.89 | 0.62 | 67.5 | |
| Body mass index | T0 | 17.0 (16.3–18.6) | 19.7 (17.4–21.5) | 0.0088 | 0.79 (0.63–0.93) | 0.025 | 0.78 (0.56–1.02) | 0.098 | 0.65 | 65.5 |
T0, inclusion. T1, T0 + 2 months. T2, end of treatment. OR, odds ratio; aOR, adjusted odds ratio; CI, confidence interval; WBC, white blood cells; C, model C statistic; AIC, Akaike Information Criterion. Only parameters with significant association to the outcome were shown; other tested parameters are available in Supplementary Table 7 . Slow culture conversion was defined as a persistently positive culture result at T1 followed by a culture conversion at T2. For MIT IFN-γ, associations were calculated for each unit increase. For lymphocyte proportions, associations were calculated for each increase of 5%. 1models were adjusted for age, sex, country of origin, drug resistance strain, body mass index at inclusion, and BCG vaccination rate.