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. 2021 Feb 15;16:7. doi: 10.1186/s13024-020-00421-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Timeline of experimental protocol. pMCAo: permanent middle cerebral artery occlusion; IP: intraperitoneal; n: number of mice/group. Long term potentiation, neuronal death and microglia/macrophage densities were studied in both hippocampus; white matter density and microglia/macrophages density were studied in both striatums; microglia/macrophage density was studied in the peri-infarct and contralateral homonymous area. Indoleamine 2, 3 dioxygenase (IDO) activity that converts Tryptophan (TRP) to Kynurenine (KYN), and kynurenine metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA) were measured in serum and brain at D40. Four groups were evaluated for each time point: control mice (C), diabetic mice (D), pMCAo mice (mice subjected to permanent middle cerebral artery occlusion without diabetes) and pMCAo + D (mice subjected to permanent middle cerebral artery occlusion with diabetes); n is the number of mice/group