Table 2.

 World Health Organization revised criteria for the diagnosis of Polycytemia Vera [3]

Major criteria

1. Hb >18.5 g/dL (men)/>16.5 g/dL (women) or Hb or Hct >99th percentile of reference range for age, sex, or altitude of residence or RBC mass >25% above mean normal predicted or Hb >17 g/dL (men)/>15 g/dL (women) if associated with a sustained increase of ≥2 g/dL from baseline that cannot be attributed to correction of iron deficiency

2. Presence of JAK2 V617F or JAK2 exon 12 mutation

Minor criteria

1. Trilineage proliferation in Bone Marrow

2. Subnormal Erythropoietin level

3. Endogenous erythroid colony growth

PV diagnosis =2 major criteria and 1 minor criterion OR the first major criterion and 2 minor criteria

Hct hematocrit, Hb hemoglobin, PV polycythemia vera, RBC red blood cell