Fig. 2.

Mean intra-subject change from baseline (95% CI) in patient-reported outcomes, baseline^a to end of study^b. Note Mean and 95% CI values can be found in Additional file 1. ^aBaseline was visit 1 (week 1) of the open-label study. ^bFinal visit (week 53 or extension period week 88 for subjects who participated in the extension period). C1-INH(SC) subcutaneous C1-inhibitor, CI confidence interval, EQ-5D European Quality of Life-5 Dimensions Questionnaire, HADS Hospital Anxiety and Depression Scale, TSQM Treatment Satisfaction Questionnaire for Medication, WPAI Work Productivity and Activity Impairment Questionnaire, CI confidence interval