Fig. 4.

T-cell infiltration is not correlated with NSD1 expression in HPV+ HNSCC, but is weakly correlated in HPV- HNSCC. A previously reported 13 gene T-cell transcript signature was calculated for each sample in the TCGA HNSCC cohort and compared pairwise with normalized RNA-seq data for NSD1, NSD2, and NSD3 for HPV+ (a) and HPV- (b) HNSCC samples. For each NSD paralog, the correlation with the T-cell transcript signature was calculated by Spearman’s Rho analysis