Table 2.

Comparison of the performance of the ACC/AHA model and ACC/AHA model with addition of NT-proBNP

	Risk thresholds
	5%	7.5%	20%
Men
Sensitivity (95% CI)
ACC/AHA	80% (78% to 82%)	50% (47% to 53%)	9% (8% to 11%)
ACC/AHA + NT-proBNP	83% (81% to 85%)	58% (55% to 61%)	16% (14% to 18%)
Specificity (95% CI)
ACC/AHA	70% (69% to 71%)	90% (89% to 91%)	99% (99% to 100%)
ACC/AHA + NT-proBNP	72% (71% to 73%)	90% (89% to 91%)	99% (99% to 100%)
Positive predicted value (95% CI)
ACC/AHA	27% (25% to 28%)	40% (37% to 43%)	88% (80% to 96%)
ACC/AHA + NT-proBNP	29% (27% to 30%)	44% (41% to 46%)	84% (79% to 90%)
Negative predicted value (95% CI)
ACC/AHA	96% (96% to 97%)	93% (92% to 93%)	89% (87% to 89%)
ACC/AHA + NT-proBNP	97% (96% to 97%)	94% (93% to 95%)	90% (89% to 90%)
Women
Sensitivity (95% CI)
ACC/AHA	81% (79% to 83%)	52% (49% to 55%)	9% (8% to 12%)
ACC/AHA + NT-proBNP	85% (83% to 87%)	63% (60% to 66%)	21% (18% to 23%)
Specificity (95% CI)
ACC/AHA	67% (66% to 78%)	89% (88% to 90%)	99% (99% to 100%)
ACC/AHA + NT-proBNP	69% (68% to 70%)	87% (86% to 88%)	99% (99% to 100%)
Positive predicted value (95% CI)
ACC/AHA	19% (18% to 20%)	31% (29% to 33%)	57% (48% to 67%)
ACC/AHA + NT-proBNP	21% (20% to 22%)	33% (31% to 35%)	69% (64% to 74%)
Negative predicted value (95% CI)
ACC/AHA	97% (97% to 98%)	95% (95% to 96%)	92% (91% to 93%)
ACC/AHA + NT-proBNP	98% (98% to 99%)	96% (95% to 96%)	93% (92% to 93%)