Table 1.
Sensitivities and specificities of ELISA, LFIA and CLiA assays for SARS-CoV-2 antibody detection shown with 95% confidence intervals (CI)
| Number of Serum Samples |
||||||
|---|---|---|---|---|---|---|
| RT-PCR confirmed cases |
Pre-COVID control |
|||||
| ASSAY | True Positive | False Negative | True Negative | False Positive | Sensitivity (95% CI) | Specificity (95% CI) |
| ELISA | ||||||
| EDITM | 67 | 14 | 49 | 1 | 82.7(72.4–89.9) | 98.0 (88.0–99.9) |
| DIA.PRO | 83 | 7 | 42 | 8 | 92.2(84.1–96.5) | 84.0 (70.3–92.4) |
| NOVALisa | 67 | 22 | 50 | 0 | 75.3(64.8–83.5) | 100.0 (91.1–100) |
| Euroimmun NC | 81 | 9 | 50 | 0 | 90.0(81.4–95.0) | 100.0 (91.1–100) |
| Euroimmun S1 | 80 | 10 | 50 | 0 | 88.9(80.1–94.3) | 100.0 (91.1–100) |
| LFIA | ||||||
| CTK Biotech | 62 | 16 | 20 | 0 | 79.5(68.5–87.5) | 100.0 (80.0–100) |
| CLIA | ||||||
| Roche | 68 | 7 | 25 | 0 | 90.7(81.1–95.8) | 100.0 (83.4–100) |
NC = Nucleocapsid. S1 = Spike Glycolipid 1