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Summary of the pipeline adopted by GBPM to identify key residues contributing to the SARS-CoV-2 Spike/Human ACE2 interface. Spike is depicted in cyan, and ACE2 in orange, based on the 6LZG PDB model (Wang et al., 2020). Residues highlighted by GBPM are then tested for mutation frequency in the worldwide SARS-CoV-2 population.
